SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation
Identifieur interne : 000407 ( Main/Exploration ); précédent : 000406; suivant : 000408SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation
Auteurs : Charlotte Moretti [France] ; Maria-Elisabetta Serrentino [France] ; Côme Ialy-Radio [France] ; Marion Delessard [France] ; Tatiana A. Soboleva [Australie] ; Frederic Tores [France] ; Marjorie Leduc [France] ; Patrick Nitschké [France] ; Joel R. Drevet [France] ; David J. Tremethick [Australie] ; Daniel Vaiman [France] ; Ayhan Kocer [France] ; Julie Cocquet [France]Source :
- Cell Death and Differentiation [ 1350-9047 ] ; 2017.
Abstract
Sperm differentiation requires unique transcriptional regulation and chromatin remodeling after meiosis to ensure proper compaction and protection of the paternal genome. Abnormal sperm chromatin remodeling can induce sperm DNA damage, embryo lethality and male infertility, yet, little is known about the factors which regulate this process. Deficiency in
Url:
DOI: 10.1038/cdd.2017.32
PubMed: 28475176
PubMed Central: 5442469
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000712
- to stream Pmc, to step Curation: 000711
- to stream Pmc, to step Checkpoint: 000098
- to stream PubMed, to step Corpus: 000A50
- to stream PubMed, to step Curation: 000A47
- to stream PubMed, to step Checkpoint: 000A47
- to stream Ncbi, to step Merge: 004760
- to stream Ncbi, to step Curation: 004760
- to stream Ncbi, to step Checkpoint: 004760
- to stream Main, to step Merge: 000402
- to stream Main, to step Curation: 000407
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation</title><author><name sortKey="Moretti, Charlotte" sort="Moretti, Charlotte" uniqKey="Moretti C" first="Charlotte" last="Moretti">Charlotte Moretti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrentino, Maria Elisabetta" sort="Serrentino, Maria Elisabetta" uniqKey="Serrentino M" first="Maria-Elisabetta" last="Serrentino">Maria-Elisabetta Serrentino</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ialy Radio, Come" sort="Ialy Radio, Come" uniqKey="Ialy Radio C" first="Côme" last="Ialy-Radio">Côme Ialy-Radio</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Delessard, Marion" sort="Delessard, Marion" uniqKey="Delessard M" first="Marion" last="Delessard">Marion Delessard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soboleva, Tatiana A" sort="Soboleva, Tatiana A" uniqKey="Soboleva T" first="Tatiana A" last="Soboleva">Tatiana A. Soboleva</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>, PO Box 334, Canberra, ACT 2601,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tores, Frederic" sort="Tores, Frederic" uniqKey="Tores F" first="Frederic" last="Tores">Frederic Tores</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Bioinformatics facility, Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leduc, Marjorie" sort="Leduc, Marjorie" uniqKey="Leduc M" first="Marjorie" last="Leduc">Marjorie Leduc</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>3P5 proteomic facility, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nitschke, Patrick" sort="Nitschke, Patrick" uniqKey="Nitschke P" first="Patrick" last="Nitschké">Patrick Nitschké</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Bioinformatics facility, Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Drevet, Joel R" sort="Drevet, Joel R" uniqKey="Drevet J" first="Joel R" last="Drevet">Joel R. Drevet</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetic Reproduction and Development, CNRS UMR6293 – INSERM U1103 – Clermont Université</institution>, 63178 Aubière Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tremethick, David J" sort="Tremethick, David J" uniqKey="Tremethick D" first="David J" last="Tremethick">David J. Tremethick</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>, PO Box 334, Canberra, ACT 2601,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kocer, Ayhan" sort="Kocer, Ayhan" uniqKey="Kocer A" first="Ayhan" last="Kocer">Ayhan Kocer</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetic Reproduction and Development, CNRS UMR6293 – INSERM U1103 – Clermont Université</institution>, 63178 Aubière Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cocquet, Julie" sort="Cocquet, Julie" uniqKey="Cocquet J" first="Julie" last="Cocquet">Julie Cocquet</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28475176</idno><idno type="pmc">5442469</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5442469</idno><idno type="RBID">PMC:5442469</idno><idno type="doi">10.1038/cdd.2017.32</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000712</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000712</idno><idno type="wicri:Area/Pmc/Curation">000711</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000711</idno><idno type="wicri:Area/Pmc/Checkpoint">000098</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000098</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000A50</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A50</idno><idno type="wicri:Area/PubMed/Curation">000A47</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A47</idno><idno type="wicri:Area/PubMed/Checkpoint">000A47</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A47</idno><idno type="wicri:Area/Ncbi/Merge">004760</idno><idno type="wicri:Area/Ncbi/Curation">004760</idno><idno type="wicri:Area/Ncbi/Checkpoint">004760</idno><idno type="wicri:doubleKey">1350-9047:2017:Moretti C:sly:regulates:genes</idno><idno type="wicri:Area/Main/Merge">000402</idno><idno type="wicri:Area/Main/Curation">000407</idno><idno type="wicri:Area/Main/Exploration">000407</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation</title><author><name sortKey="Moretti, Charlotte" sort="Moretti, Charlotte" uniqKey="Moretti C" first="Charlotte" last="Moretti">Charlotte Moretti</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Serrentino, Maria Elisabetta" sort="Serrentino, Maria Elisabetta" uniqKey="Serrentino M" first="Maria-Elisabetta" last="Serrentino">Maria-Elisabetta Serrentino</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ialy Radio, Come" sort="Ialy Radio, Come" uniqKey="Ialy Radio C" first="Côme" last="Ialy-Radio">Côme Ialy-Radio</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Delessard, Marion" sort="Delessard, Marion" uniqKey="Delessard M" first="Marion" last="Delessard">Marion Delessard</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soboleva, Tatiana A" sort="Soboleva, Tatiana A" uniqKey="Soboleva T" first="Tatiana A" last="Soboleva">Tatiana A. Soboleva</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>, PO Box 334, Canberra, ACT 2601,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tores, Frederic" sort="Tores, Frederic" uniqKey="Tores F" first="Frederic" last="Tores">Frederic Tores</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Bioinformatics facility, Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leduc, Marjorie" sort="Leduc, Marjorie" uniqKey="Leduc M" first="Marjorie" last="Leduc">Marjorie Leduc</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>3P5 proteomic facility, Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nitschke, Patrick" sort="Nitschke, Patrick" uniqKey="Nitschke P" first="Patrick" last="Nitschké">Patrick Nitschké</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Bioinformatics facility, Université Paris Descartes, Sorbonne Paris Cité, Institut Imagine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Drevet, Joel R" sort="Drevet, Joel R" uniqKey="Drevet J" first="Joel R" last="Drevet">Joel R. Drevet</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetic Reproduction and Development, CNRS UMR6293 – INSERM U1103 – Clermont Université</institution>, 63178 Aubière Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tremethick, David J" sort="Tremethick, David J" uniqKey="Tremethick D" first="David J" last="Tremethick">David J. Tremethick</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>The John Curtin School of Medical Research, The Australian National University</institution>, PO Box 334, Canberra, ACT 2601,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kocer, Ayhan" sort="Kocer, Ayhan" uniqKey="Kocer A" first="Ayhan" last="Kocer">Ayhan Kocer</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Genetic Reproduction and Development, CNRS UMR6293 – INSERM U1103 – Clermont Université</institution>, 63178 Aubière Cedex,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cocquet, Julie" sort="Cocquet, Julie" uniqKey="Cocquet J" first="Julie" last="Cocquet">Julie Cocquet</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Development, Reproduction and Cancer,<institution>INSERM, U1016, Institut Cochin</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>CNRS, UMR8104</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine</institution>, Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Death and Differentiation</title><idno type="ISSN">1350-9047</idno><idno type="eISSN">1476-5403</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Sperm differentiation requires unique transcriptional regulation and chromatin remodeling after meiosis to ensure proper compaction and protection of the paternal genome. Abnormal sperm chromatin remodeling can induce sperm DNA damage, embryo lethality and male infertility, yet, little is known about the factors which regulate this process. Deficiency in <italic>Sly</italic>, a mouse Y chromosome-encoded gene expressed only in postmeiotic male germ cells, has been shown to result in the deregulation of hundreds of sex chromosome-encoded genes associated with multiple sperm differentiation defects and subsequent male infertility. The underlying mechanism remained, to date, unknown. Here, we show that SLY binds to the promoter of sex chromosome-encoded and autosomal genes highly expressed postmeiotically and involved in chromatin regulation. Specifically, we demonstrate that <italic>Sly</italic> knockdown directly induces the deregulation of sex chromosome-encoded H2A variants and of the H3K79 methyltransferase DOT1L. The modifications prompted by loss of <italic>Sly</italic> alter the postmeiotic chromatin structure and ultimately result in abnormal sperm chromatin remodeling with negative consequences on the sperm genome integrity. Altogether our results show that SLY is a regulator of sperm chromatin remodeling. Finally we identified that SMRT/N-CoR repressor complex is involved in gene regulation during sperm differentiation since members of this complex, in particular TBL1XR1, interact with SLY in postmeiotic male germ cells.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Moretti, Charlotte" sort="Moretti, Charlotte" uniqKey="Moretti C" first="Charlotte" last="Moretti">Charlotte Moretti</name></noRegion><name sortKey="Cocquet, Julie" sort="Cocquet, Julie" uniqKey="Cocquet J" first="Julie" last="Cocquet">Julie Cocquet</name><name sortKey="Cocquet, Julie" sort="Cocquet, Julie" uniqKey="Cocquet J" first="Julie" last="Cocquet">Julie Cocquet</name><name sortKey="Cocquet, Julie" sort="Cocquet, Julie" uniqKey="Cocquet J" first="Julie" last="Cocquet">Julie Cocquet</name><name sortKey="Delessard, Marion" sort="Delessard, Marion" uniqKey="Delessard M" first="Marion" last="Delessard">Marion Delessard</name><name sortKey="Delessard, Marion" sort="Delessard, Marion" uniqKey="Delessard M" first="Marion" last="Delessard">Marion Delessard</name><name sortKey="Delessard, Marion" sort="Delessard, Marion" uniqKey="Delessard M" first="Marion" last="Delessard">Marion Delessard</name><name sortKey="Drevet, Joel R" sort="Drevet, Joel R" uniqKey="Drevet J" first="Joel R" last="Drevet">Joel R. Drevet</name><name sortKey="Ialy Radio, Come" sort="Ialy Radio, Come" uniqKey="Ialy Radio C" first="Côme" last="Ialy-Radio">Côme Ialy-Radio</name><name sortKey="Ialy Radio, Come" sort="Ialy Radio, Come" uniqKey="Ialy Radio C" first="Côme" last="Ialy-Radio">Côme Ialy-Radio</name><name sortKey="Ialy Radio, Come" sort="Ialy Radio, Come" uniqKey="Ialy Radio C" first="Côme" last="Ialy-Radio">Côme Ialy-Radio</name><name sortKey="Kocer, Ayhan" sort="Kocer, Ayhan" uniqKey="Kocer A" first="Ayhan" last="Kocer">Ayhan Kocer</name><name sortKey="Leduc, Marjorie" sort="Leduc, Marjorie" uniqKey="Leduc M" first="Marjorie" last="Leduc">Marjorie Leduc</name><name sortKey="Moretti, Charlotte" sort="Moretti, Charlotte" uniqKey="Moretti C" first="Charlotte" last="Moretti">Charlotte Moretti</name><name sortKey="Moretti, Charlotte" sort="Moretti, Charlotte" uniqKey="Moretti C" first="Charlotte" last="Moretti">Charlotte Moretti</name><name sortKey="Nitschke, Patrick" sort="Nitschke, Patrick" uniqKey="Nitschke P" first="Patrick" last="Nitschké">Patrick Nitschké</name><name sortKey="Serrentino, Maria Elisabetta" sort="Serrentino, Maria Elisabetta" uniqKey="Serrentino M" first="Maria-Elisabetta" last="Serrentino">Maria-Elisabetta Serrentino</name><name sortKey="Serrentino, Maria Elisabetta" sort="Serrentino, Maria Elisabetta" uniqKey="Serrentino M" first="Maria-Elisabetta" last="Serrentino">Maria-Elisabetta Serrentino</name><name sortKey="Serrentino, Maria Elisabetta" sort="Serrentino, Maria Elisabetta" uniqKey="Serrentino M" first="Maria-Elisabetta" last="Serrentino">Maria-Elisabetta Serrentino</name><name sortKey="Tores, Frederic" sort="Tores, Frederic" uniqKey="Tores F" first="Frederic" last="Tores">Frederic Tores</name><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name></country><country name="Australie"><noRegion><name sortKey="Soboleva, Tatiana A" sort="Soboleva, Tatiana A" uniqKey="Soboleva T" first="Tatiana A" last="Soboleva">Tatiana A. Soboleva</name></noRegion><name sortKey="Tremethick, David J" sort="Tremethick, David J" uniqKey="Tremethick D" first="David J" last="Tremethick">David J. Tremethick</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000407 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000407 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5442469
|texte= SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28475176" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |